Blood analysis sensor

The future is in
our blood

The blood flowing through our veins carries vital elements, such as glucose, lactate, urea and many others. At the same time, our blood serves as a data stream, carrying important information about our metabolism, levels of fatigue and status of critical organ condition – kidneys, liver, pancreas.

Imagine the enormous health benefits that could be achieved if one could measure this data in real-time – from unprecedented diabetes management and nutrition monitoring, to never-before-seen fitness and wellness insights.

Brolis Sensor Technology is turning this possibility into reality. Our devoted team is developing an ultra-compact laser-based integrated sensor technology for multi-molecule sensing throughout the entire bloodstream. It will make blood analysis more accurate, simple and easier to perform for everyone.

Life: healthier, smarter
and more sustainable

At Brolis, we are pioneering a new piece of technology that will help more than two billion people live better lives. Thanks to our innovation, blood analysis can be transformed into a relatively simple task that generates more information, thus providing people with more opportunities to take better care of their health by means of personalized healthcare.

Our multi-molecule sensor is targeted to be accessible and affordable for everyone. This versatile, accurate and extremely compact integrated sensor will bring dramatic change to healthcare since every molecule we monitor addresses different processes and body systems. With our sensor, it will be easier to measure these elements:

With our sensor, it will be easier to measure these elements:

Glucose for diabetes patients

According to the World Health Organization (WHO), as of 2014 there were 422 million people diagnosed with diabetes and that number is rising. These people are waiting for a better and more convenient way to test blood glucose levels several times a day.

Diabetes is a physically and mentally exhausting sickness that irreversibly shakes the lives of those affected by it. Finding a way to analyze blood effortlessly would drastically change their quality of life and empower them to feel fully comfortable again.

Diabetes is a chronic disease that occurs when either the pancreas cannot produce enough insulin (a hormone that regulates glucose levels in blood) or the body’s ability to utilize it malfunctions.

High blood glucose levels eventually lead to serious damage to body systems and may eventually lead to severe consequences such as blindness, kidney failure, heart attack, stroke and leg amputation. Even when diagnosed early, diabetes changes life dramatically, requiring individuals to regularly perform finger-prick tests, draw blood, monitor blood glucose levels, administer insulin and other medication, as well as adapt their diets.

Very few people affected by diabetes can afford the currently available “artificial pancreas” implantable devices. Our ambition is to enable everyone to easily monitor their blood glucose levels in real-time. It would give them the data they need to make timely decisions on when and how to change their diet and levels of activity, even before pre-diabetes or diabetes develops. If someone already has the condition, our goal is to help them manage it as easily as possible by providing real-time glucose level monitoring data without the need of finger pricking.

Lactates for sports performance monitoring

Measuring lactate concentrations opens doors to next-level workouts for anyone who exercises. It would give them the power to check and regulate their fitness and fatigue condition in real time.

Just imagine if anyone with a smartwatch could access data to better understand their body and monitor performance. That’s more than 100 million users worldwide.

Understanding the body’s limits is vital for amateur and professional athletes alike. It lets them know how far their limits can be pushed while putting them in a position to avoid excessive stress, which can lead to overtiring, inefficient training, or even worse – a serious injury.

Lactate levels are a direct indicator of muscle fatigue and are vital for the evaluation of an athlete’s performance. Being able to monitor blood lactate levels in real-time can lead to new performance records, faster and more efficient recovery, and fewer injuries.

Using Brolis’ mass-market scalable integrated sensor technology, we can support every professional and amateur athlete, and together with glucose and other constituent data, provide valuable insights that have never been available before to help you become the next olympic or neighborhood champion.

Lactates for sepsis management

Sepsis is a silent killer. As such, there are hundreds of millions of people whose lives can be saved by more accurate blood analysis. Across the globe, over 30 million cases of sepsis are diagnosed annually, and the mortality rate among those suffering from the condition is 33%.

Being able to precisely measure lactate levels in real-time would allow sepsis to be monitored properly and spotted in its early stages, which is essential for treatment to be efficient.

Sepsis arises when the body’s response to an infection is to injure its own tissues and organs. If not detected early and managed promptly, it can lead to septic shock, multiple organ failure, and even death.

One in three septic patients dies. This means approximately 10 million casualties every year. In the USA alone, this accounts for 24 billion dollars of medical costs. If diagnosed early, the chances of survival greatly increase and the financial burden dramatically decreases.

One of the early indicators of sepsis is a rising or elevated blood lactate level, which is why it is recommended to measure this first when testing for the condition. Our integrated sensor can provide early elevated lactate level warning and potentially save lives and cut medical expenses.

Urea for renal function diagnostics

Nearly a billion people worldwide are affected by kidney related problems. Chronic Kidney Disease (CKD) is one such major issue; it leads to over a million deaths every year.

Monitoring blood urea levels would provide useful insights about kidney function and would make early warning and diagnostics of a disease easier. This is especially critical for diabetes patients, who are at a greatly elevated risk of CKD due to higher blood sugar levels.

Chronic Kidney Disease (CKD) involves a gradual loss of kidney function over an extended period of time – sometimes taking months, and other times up to a few years. If not diagnosed early, the disease can lead to patients requiring dialysis or even kidney transplants.

Every year, CKD takes over a million lives, whereas nearly a billion people worldwide are affected. Half of these cases are related to diabetes, putting these people at a much higher risk.

Brolis’ multi-molecule swept wavelength sensor could make a dramatic difference for people at risk of CKD, allowing them to get an early warning of abnormal kidney function while simultaneously helping them manage blood sugar levels. This would allow for preventative measures to be taken, enormously improving quality of life and reducing the risk of dialysis, kidney transplant or even death.

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  • Glucose for diabetes patients

    According to World Health Organization (WHO), as of 2014 there were 422 million people diagnosed with diabetes and rising. These people are waiting for a better...

    Read more

  • Lactates for sports performance monitoring

    Measuring lactate concentrations opens doors to next-level workouts for anyone who exercises. It would give them...

    Read more

  • Lactates for sepsis management

    Sepsis is a silent killer. As such, there are hundreds of millions of people whose lives can be saved by more accurate blood analysis...

    Read more

  • Urea for renal function diagnostics

    Nearly a billion people worldwide are affected by kidney related problems. Monitoring blood urea levels...

    Read more

  • Glucose for diabetes patients

    Glucose for diabetes patients

    According to the World Health Organization (WHO), as of 2014 there were 422 million people diagnosed with diabetes and that number is rising. These people are waiting for a better and more convenient way to test blood glucose levels several times a day.

    Diabetes is a physically and mentally exhausting sickness that irreversibly shakes the lives of those affected by it. Finding a way to analyze blood effortlessly would drastically change their quality of life and empower them to feel fully comfortable again.

    Diabetes is a chronic disease that occurs when either the pancreas cannot produce enough insulin (a hormone that regulates glucose levels in blood) or the body’s ability to utilize it malfunctions.

    High blood glucose levels eventually lead to serious damage to body systems and may eventually lead to severe consequences such as blindness, kidney failure, heart attack, stroke and leg amputation. Even when diagnosed early, diabetes changes life dramatically, requiring individuals to regularly perform finger-prick tests, draw blood, monitor blood glucose levels, administer insulin and other medication, as well as adapt their diets.

    Very few people affected by diabetes can afford the currently available “artificial pancreas” implantable devices. Our ambition is to enable everyone to easily monitor their blood glucose levels in real-time. It would give them the data they need to make timely decisions on when and how to change their diet and levels of activity, even before pre-diabetes or diabetes develops. If someone already has the condition, our goal is to help them manage it as easily as possible by providing real-time glucose level monitoring data without the need of finger pricking.

  • Lactates for sports performance monitoring

    Lactates for sports performance monitoring

    Measuring lactate concentrations opens doors to next-level workouts for anyone who exercises. It would give them the power to check and regulate their fitness and fatigue condition in real time.

    Just imagine if anyone with a smartwatch could access data to better understand their body and monitor performance. That’s more than 100 million users worldwide.

    Understanding the body’s limits is vital for amateur and professional athletes alike. It lets them know how far their limits can be pushed while putting them in a position to avoid excessive stress, which can lead to overtiring, inefficient training, or even worse – a serious injury.

    Lactate levels are a direct indicator of muscle fatigue and are vital for the evaluation of an athlete’s performance. Being able to monitor blood lactate levels in real-time can lead to new performance records, faster and more efficient recovery, and fewer injuries.

    Using Brolis’ mass-market scalable integrated sensor technology, we can support every professional and amateur athlete, and together with glucose and other constituent data, provide valuable insights that have never been available before to help you become the next olympic or neighborhood champion.

  • Lactates for sepsis management

    Lactates for sepsis management

    Sepsis is a silent killer. As such, there are hundreds of millions of people whose lives can be saved by more accurate blood analysis. Across the globe, over 30 million cases of sepsis are diagnosed annually, and the mortality rate among those suffering from the condition is 33%.

    Being able to precisely measure lactate levels in real-time would allow sepsis to be monitored properly and spotted in its early stages, which is essential for treatment to be efficient.

    Sepsis arises when the body’s response to an infection is to injure its own tissues and organs. If not detected early and managed promptly, it can lead to septic shock, multiple organ failure, and even death.

    One in three septic patients dies. This means approximately 10 million casualties every year. In the USA alone, this accounts for 24 billion dollars of medical costs. If diagnosed early, the chances of survival greatly increase and the financial burden dramatically decreases.

    One of the early indicators of sepsis is a rising or elevated blood lactate level, which is why it is recommended to measure this first when testing for the condition. Our integrated sensor can provide early elevated lactate level warning and potentially save lives and cut medical expenses.

  • Urea for renal function diagnostics

    Urea for renal function diagnostics

    Nearly a billion people worldwide are affected by kidney related problems. Chronic Kidney Disease (CKD) is one such major issue; it leads to over a million deaths every year.

    Monitoring blood urea levels would provide useful insights about kidney function and would make early warning and diagnostics of a disease easier. This is especially critical for diabetes patients, who are at a greatly elevated risk of CKD due to higher blood sugar levels.

    Chronic Kidney Disease (CKD) involves a gradual loss of kidney function over an extended period of time – sometimes taking months, and other times up to a few years. If not diagnosed early, the disease can lead to patients requiring dialysis or even kidney transplants.

    Every year, CKD takes over a million lives, whereas nearly a billion people worldwide are affected. Half of these cases are related to diabetes, putting these people at a much higher risk.

    Brolis’ multi-molecule swept wavelength sensor could make a dramatic difference for people at risk of CKD, allowing them to get an early warning of abnormal kidney function while simultaneously helping them manage blood sugar levels. This would allow for preventative measures to be taken, enormously improving quality of life and reducing the risk of dialysis, kidney transplant or even death.

Brolis’ integrated sensor is based on swept-wavelength infrared laser absorption spectroscopy. Each molecule has a unique absorption spectrum due to its various rotational-vibrational movements. This unique absorption spectrum can be used as a fingerprint for species and concentration identification.

  1. A small portable swept-wavelength laser shines into tissue with capillary network and interacts with target molecules that have resonant absorption.
  2. The reflected light carrying molecule species and concentration information is collected back in a sensor-on-chip and a real-time signal analysis is carried out.
  3. Sensing is performed in a fraction of a second, which means the sensor system-on-chip offers real-time measurements.
  • Brolis’ integrated sensor is able to cover a wavelength range of over 500 nm in a fraction of a second.
  •  We measure the full shape of the absorption spectrum and not just several points.
  •  It is real-time. The Brolis system’s tuning speed allows us to record thousands of spectra in a second, which makes achieving real-time data possible.

We present a new technological solution that will lift blood analysis to a higher level, making it easily accessible to everyone.

  • Coverage of unique spectral region between 1.7 to 2.5 micrometers Here, in contrast to shorter-wavelength range, strong overtone and combination absorption bands of desired molecules exist. Moreover, water has a local absorption minimum in this spectral region, what allows extracting molecule specie and concentration data.
  • Laser-based absorption spectroscopy Molecules in liquid media have broad absorption spectral bands that span hundreds of nanometers. The shape of this broad signal carries information about the species and concentration, and acts as a fingerprint.
  • Integrated ultra-widely swept laser sources In order to use full spectral information, we developed unique integrated ultra-widely swept laser sources. They are based on our proprietary know-how of GaSb materials and silicon photonics.
    We use an ultra-narrow single-mode laser line (SMSR > 40 dB) that we sweep across the entire spectral range and take advantage of the highest possible spectral power density and signal-to-noise ratio that the laws of physics allow.
    Finally, our sensor approach requires the lowest amount of discrete III-V components possible, making it the most efficient solution in terms of footprint and functionality.

To tackle the sensor problem, we created a technology that did not exist before. We build everything ourselves – from exotic GaSb (Gallium Antimonide) based material synthesis, to the world’s first ultra-widely swept hybrid GaSb-Si Photonics integrated laser.

The latter allowed us to create the world’s first laser-based sensors realized in a silicon photonics chip that is smaller than 5 sq. mm. All this know-how is proprietary to Brolis and was developed purely in-house.

  •  Accessible It can be used at any point of care
  •  Portable It does not require special premises to operate in
  •  Time saving It measures blood in real-time
  •  User-friendly It does not require the expertise of laboratory technicians
  •  Affordable Low-cost hardware
  • How it works?

    Brolis’ integrated sensor is based on swept-wavelength infrared laser absorption spectroscopy. Each molecule has a unique absorption spectrum due to its various rotational-vibrational movements. This unique absorption spectrum can be used as a fingerprint for species and concentration identification.

    1. A small portable swept-wavelength laser shines into tissue with capillary network and interacts with target molecules that have resonant absorption.
    2. The reflected light carrying molecule species and concentration information is collected back in a sensor-on-chip and a real-time signal analysis is carried out.
    3. Sensing is performed in a fraction of a second, which means the sensor system-on-chip offers real-time measurements.
  • Why it works?
    • Brolis’ integrated sensor is able to cover a wavelength range of over 500 nm in a fraction of a second.
    •  We measure the full shape of the absorption spectrum and not just several points.
    •  It is real-time. The Brolis system’s tuning speed allows us to record thousands of spectra in a second, which makes achieving real-time data possible.

    We present a new technological solution that will lift blood analysis to a higher level, making it easily accessible to everyone.

    • Coverage of unique spectral region between 1.7 to 2.5 micrometers Here, in contrast to shorter-wavelength range, strong overtone and combination absorption bands of desired molecules exist. Moreover, water has a local absorption minimum in this spectral region, what allows extracting molecule specie and concentration data.
    • Laser-based absorption spectroscopy Molecules in liquid media have broad absorption spectral bands that span hundreds of nanometers. The shape of this broad signal carries information about the species and concentration, and acts as a fingerprint.
    • Integrated ultra-widely swept laser sources In order to use full spectral information, we developed unique integrated ultra-widely swept laser sources. They are based on our proprietary know-how of GaSb materials and silicon photonics.
      We use an ultra-narrow single-mode laser line (SMSR > 40 dB) that we sweep across the entire spectral range and take advantage of the highest possible spectral power density and signal-to-noise ratio that the laws of physics allow.
      Finally, our sensor approach requires the lowest amount of discrete III-V components possible, making it the most efficient solution in terms of footprint and functionality.
  • Technologically few steps ahead

    To tackle the sensor problem, we created a technology that did not exist before. We build everything ourselves – from exotic GaSb (Gallium Antimonide) based material synthesis, to the world’s first ultra-widely swept hybrid GaSb-Si Photonics integrated laser.

    The latter allowed us to create the world’s first laser-based sensors realized in a silicon photonics chip that is smaller than 5 sq. mm. All this know-how is proprietary to Brolis and was developed purely in-house.

  • Brolis Sensor is
    •  Accessible It can be used at any point of care
    •  Portable It does not require special premises to operate in
    •  Time saving It measures blood in real-time
    •  User-friendly It does not require the expertise of laboratory technicians
    •  Affordable Low-cost hardware
We have successfully demonstrated in-vivo transdermal sensing of glucose in whole blood with excellent performance! We are now working on the ultimate wearable system-on-the-chip solution!
Testing

Our blood sensor has been currently tested with four different bio-molecules: glucose, lactate, urea and serum albumin. We perform thousands of tests in different conditions to build reliable statistics and provide an accurate result. When we say we are able to sense glucose - this means we actually sense glucose in whole blood and not synthetic aqueous solution. We are aware of the general skepticism around the topic of non-invasive glucose sensing. We chose a bottom-up approach to solve the problem - we created the technology from scratch - starting from literally atom-by-atom synthesis of the laser crystal itself with our in-house MBE technology and ending up with a fully integrated system-on-a-chip that actually senses glucose from whole blood. Click see more for our latest sensor data.

Results

Very high blood glucose prediction accuracy in-vivo (transdermal).

  • Determination coefficient R² =
    0.98 (98% prediction accuracy)
  • RMSEP = 0.7 mmol/l or 13 mg/dl (prediction error)
  • MARD = 5.7%
  • > 97% of data points within area A (clinically reliable)
Timeline